First add the toolchain bin directory to the path and set SYSROOT to the proper SDK directory.
You will also need to build and install libffi (included in the deps folder) to your sysroot for EDA to build.
sudo make prefix=$SYSROOT install
Please note that debugger integration only supports GDB and will not work with LLDB, so you should install GDB as well.
At this point Ecere requires X11 to run on OS X. We are working towards a native Cocoa driver and iOS support.